Influence of CD4 or CD8 deficiency on collagen-induced arthritis

Perforin deficiency attenuates collagen-induced arthritis

Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease, namely tissue destruction and synovial hyperplasia. In this study we examined the role of perforin (pfp), a key molecu...

Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio.

The Eae2 locus on mouse chromosome 15 controls the development of experimental autoimmune encephalomyelitis (EAE); however, in this study we show that it also controls collagen-induced arthritis (CIA). To find the smallest disease-controlling locus/loci within Eae2, we have studied development of CIA in 676 mice from a partially advanced intercross. Eae2 congenic mice were bred with mice congen...

effect of tindurin on immunopathogenesis mechanism of collagen-induced arthritis

rheumatoid arthritis is a chronic inflammatory disease characterized by the sequestration of various leukocyte subpopulations within both the developing pannus and synovial space. this study was undertaken to examine the therapeutic potency of tindurin in experimental rheumatoid arthritis. collagen-induced arthritis (cia) was induced by intradermally immunization of lewis rats at the base of th...

Collagen Antibody Induced Arthritis

Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis

BACKGROUND There is increasing evidence that the non-neuronal cholinergic system might be of importance for the pathology of rheumatoid arthritis. The role of M3 muscarinic acetylcholine receptor (M3R) in this regard has, however, not been investigated to date. Thus, in the present study we analyzed if M3R deficiency might have a protective effect on experimentally induced arthritis. METHODS ...